|
|
Biochanin_A + reduced_flavodoxin + O2 <=> 2''-hydroxybiochanin_A + flavin + H2O
|
1.14.14.89
4'-methoxyisoflavone 2'-hydroxylase
1.14.14.90
isoflavone 2'-hydroxylase
|
–
–
|
| |
BRENDA:
BS186718
KEGG:
R06561
|
|
|
|
formononetin + reduced_flavodoxin + O2 <=> Calycosin + flavin + H2O
|
1.14.14.88
isoflavone 3'-hydroxylase
|
–
|
| |
BRENDA:
BR29141
KEGG:
R03006
|
|
|
|
(-)-Maackiain-3-O-glucosyl-6''''-O-malonate <=> (-)-maackiain_3-O-beta-D-glucoside
|
not assigned
|
–
|
| |
KEGG:
R07755
|
|
|
|
(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + reduced_flavodoxin + O2 <=> glyceollin_III + flavin + 2 H2O
|
1.14.14.135
glyceollin synthase
|
–
|
| |
BRENDA:
BR52438
KEGG:
R07196
|
|
|
|
glycitin + malonyl-CoA <=> Malonylglycitin + CoA
|
2.3.1.115
isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase
|
–
|
| |
KEGG:
R07719
|
|
|
|
S-adenosyl-L-methionine + (+)-6a-hydroxymaackiain <=> H+ + (+)-pisatin + S-adenosyl-L-homocysteine
|
2.1.1.270
(+)-6a-hydroxymaackiain 3-O-methyltransferase
|
–
|
| |
BRENDA:
BR49300
KEGG:
R07750
MetaCyc:
RXN-4002
SABIO-RK:
14605
|
|
|
|
UDP-glucose + formononetin <=> H+ + formononetin_7-O-glucoside + UDP
|
2.4.1.170
isoflavone 7-O-glucosyltransferase
2.4.1.35
phenol beta-glucosyltransferase
|
–
–
|
| |
BRENDA:
BS322256
KEGG:
R07729
MetaCyc:
RXN-4761
|
|
|
|
formononetin + reduced_flavodoxin + O2 <=> 2''-hydroxyformononetin + flavin + H2O
|
1.14.14.89
4'-methoxyisoflavone 2'-hydroxylase
1.14.14.90
isoflavone 2'-hydroxylase
|
–
–
|
| |
BRENDA:
BR29142
KEGG:
R06560
|
|
|
|
naringenin + 2-oxoglutarate + O2 <=> apigenin + succinate + CO2 + H2O + H+
|
1.14.20.4
anthocyanidin synthase
1.14.20.5
flavone synthase I
|
–
–
|
| |
BRENDA:
BS371268
KEGG:
R02445
MetaCyc:
RXN-7686
|
|
|
|
S-adenosyl-L-methionine + genistein <=> H+ + Biochanin_A + S-adenosyl-L-homocysteine
|
2.1.1.155
kaempferol 4'-O-methyltransferase
2.1.1.212
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
2.1.1.231
flavonoid 4'-O-methyltransferase
2.1.1.46
isoflavone 4'-O-methyltransferase
|
–
–
–
–
|
| |
BRENDA:
BS289635
KEGG:
R02931
MetaCyc:
RXN-3645
|
|
|
|
pseudobaptigenin + reduced_flavodoxin + O2 <=> 2'',7-Dihydroxy-4'',5''-methylenedioxyisoflavone + flavin + H2O
|
1.14.14.90
isoflavone 2'-hydroxylase
|
–
|
| |
KEGG:
R07746
|
|
|
|
UDP-glucose + Biochanin_A <=> biochanin_A_7-O-beta-D-glucopyranoside + UDP
|
2.4.1.170
isoflavone 7-O-glucosyltransferase
|
–
|
| |
BRENDA:
BS322255
KEGG:
R06795
MetaCyc:
RXN-4702
|
|
|
|
7-hydroxy-2,4,5''-trimethoxyisoflavone <=> 9-Demethylmunduserone
|
not assigned
|
–
|
| |
KEGG:
R07736
MetaCyc:
RXN-9057
|
|
|
|
(3R,4R)-7,2''-dihydroxy-4''-methoxyisoflavanol + NADP+ <=> vestitone + NADPH + H+
|
1.1.1.348
(3R)-2'-hydroxyisoflavanone reductase
|
–
|
| |
BRENDA:
BS421737
KEGG:
R07737
MetaCyc:
RXN-3601
|
|
|
|
(-)-maackiain_3-O-beta-D-glucoside + malonyl-CoA <=> (-)-maackiain-3-O-glucoside-6''''-malonate + CoA
|
2.3.1.115
isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase
|
–
|
| |
BRENDA:
BS320329
KEGG:
R07754
MetaCyc:
RXN-4320
|
|
|
|
naringenin + O2 + reduced_flavodoxin <=> 2,4'',5,7-tetrahydroxyisoflavanone + H2O + flavin
|
1.14.14.87
2-hydroxyisoflavanone synthase
|
–
|
| |
BRENDA:
BR50515
KEGG:
R07778
|
|
|
|
genistein + reduced_flavodoxin + O2 <=> 2''-hydroxygenistein + flavin + H2O
|
1.14.14.89
4'-methoxyisoflavone 2'-hydroxylase
1.14.14.90
isoflavone 2'-hydroxylase
|
–
–
|
| |
BRENDA:
BS186720
KEGG:
R06607
|
|
|
|
daidzein + reduced_flavodoxin + O2 <=> 2''-hydroxydaidzein + flavin + H2O
|
1.14.14.89
4'-methoxyisoflavone 2'-hydroxylase
1.14.14.90
isoflavone 2'-hydroxylase
|
–
–
|
| |
BRENDA:
BS186719
KEGG:
R06606
|
|
|
|
(3R,4R)-7,2''-dihydroxy-4''-methoxyisoflavanol <=> medicarpin + H2O
|
4.2.1.139
pterocarpan synthase
|
–
|
| |
BRENDA:
BS422705;
BS444182
KEGG:
R07738
MetaCyc:
RXN-3602
|
|
|
|
(+)-Sophorol + NADPH + H+ <=> (+)-maackiain + NADP+ + H2O
|
not assigned
|
–
|
| |
KEGG:
R07748
|
|
|
|
vestitone + NADP+ <=> 2'-hydroxyformononetin + NADPH + H+
|
1.3.1.45
2'-hydroxyisoflavone reductase
1.3.1.51
2'-hydroxydaidzein reductase
|
–
–
|
| |
BRENDA:
BR36827
KEGG:
R06562
MetaCyc:
RXN-3562
|
|
|
|
UDP-glucose + genistein <=> genistin + UDP
|
2.4.1.170
isoflavone 7-O-glucosyltransferase
|
–
|
| |
BRENDA:
BS322257
KEGG:
R02932
MetaCyc:
RXN-3581
SABIO-RK:
2791
|
|
|
|
glycitein + UDP-glucose <=> glycitin + UDP
|
2.4.1.170
isoflavone 7-O-glucosyltransferase
|
–
|
| |
KEGG:
R07718
|
|
|
|
6,7,4''-Trihydroxyflavanone + O2 + reduced_flavodoxin <=> 2,6,7,4''-Tetrahydroxyisoflavanone + H2O + flavin
|
1.14.14.87
2-hydroxyisoflavanone synthase
|
–
|
| |
KEGG:
R07715
|
|
|
|
S-adenosyl-L-methionine + 2'-hydroxydihydrodaidzein <=> H+ + (2R,3S)-2,7-dihydroxy-4''-methoxyisoflavanone + S-adenosyl-L-homocysteine
|
2.1.1.212
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
|
–
|
| |
BRENDA:
BR49705
KEGG:
R07722
MetaCyc:
RXN-3624
SABIO-RK:
14604
|
|
|
|
2,5,7,4'-tetrahydroxyisoflavanone <=> genistein + H2O + H+
|
4.2.1.105
2-hydroxyisoflavanone dehydratase
|
–
|
| |
BRENDA:
BR50563
KEGG:
R06793
MetaCyc:
RXN-3303
SABIO-RK:
10560
|
|
|
|
S-adenosyl-L-methionine + daidzein <=> H+ + isoformononetin + S-adenosyl-L-homocysteine
|
2.1.1.150
isoflavone 7-O-methyltransferase
2.1.1.B75
|
–
–
|
| |
BRENDA:
BS413574
KEGG:
R07724
MetaCyc:
RXN-3481
|
|
|
|
Calycosin + reduced_flavodoxin + O2 <=> pseudobaptigenin + flavin + 2 H2O
|
1.14.19.63
pseudobaptigenin synthase
|
–
|
| |
BRENDA:
BR49422
KEGG:
R07745
|
|
|
|
(3R)-2''-hydroxydihydrodaidzein + NADP+ <=> 2''-hydroxydaidzein + NADPH + H+
|
1.3.1.51
2'-hydroxydaidzein reductase
|
–
|
| |
BRENDA:
BR1199
KEGG:
R03962
MetaCyc:
RXN-4502
|
|
|
|
2''-Hydroxydihydrodaidzein + NADPH + H+ <=> demethylmedicarpin + NADP+ + H2O
|
not assigned
|
–
|
| |
KEGG:
R07728
|
|
|
|
Calycosin <=> rotenone
|
not assigned
|
–
|
| |
KEGG:
R07744
|
|
|
|
2-(or_4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + reduced_flavodoxin + O2 <=> glyceollin + flavin + 2 H2O
|
1.14.14.135
glyceollin synthase
|
–
|
| |
BRENDA:
BR52439
KEGG:
R07197;
R07357
|
|
|
|
formononetin_7-O-glucoside <=> formononetin
|
not assigned
|
–
|
| |
KEGG:
R07733
|
|
|
|
(-)-Medicocarpin + malonyl-CoA <=> (-)-medicarpin-3-O-glucoside-6''''-malonate + CoA
|
2.3.1.115
isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase
|
–
|
| |
KEGG:
R07741
MetaCyc:
RXN-4204
|
|
|
|
(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl_diphosphate <=> (6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate
|
2.5.1.36
trihydroxypterocarpan dimethylallyltransferase
|
–
|
| |
BRENDA:
BR44283
KEGG:
R07271
MetaCyc:
RXN-4510
|
|
|
|
Formononetin_7-O-glucoside-6''''-O-malonate <=> formononetin_7-O-glucoside
|
not assigned
|
–
|
| |
KEGG:
R07732
|
|
|
|
demethylmedicarpin + reduced_flavodoxin + O2 <=> (6aS,11aS)-3,6a,9-trihydroxypterocarpan + flavin + H2O
|
1.14.14.93
3,9-dihydroxypterocarpan 6a-monooxygenase
|
–
|
| |
BRENDA:
BR36760
KEGG:
R03452
|
|
|
|
liquiritigenin + O2 + reduced_flavodoxin <=> 2,4'',7-trihydroxyisoflavanone + H2O + flavin
|
1.14.14.87
2-hydroxyisoflavanone synthase
|
–
|
| |
BRENDA:
BR49825
KEGG:
R07777
|
|
|
|
daidzin + malonyl-CoA <=> daidzein-7-O-glucosyl-6''-O-malonate + CoA
|
2.3.1.115
isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase
|
–
|
| |
BRENDA:
BS320328
KEGG:
R07721
MetaCyc:
RXN-3585
|
|
|
|
liquiritigenin + NADPH + H+ + O2 <=> 6,7,4''-Trihydroxyflavanone + NADP+ + H2O
|
1.14.13
|
–
|
| |
KEGG:
R07711
|
|
|
|
S-adenosyl-L-methionine + daidzein <=> H+ + formononetin + S-adenosyl-L-homocysteine
|
2.1.1.212
2,7,4'-trihydroxyisoflavanone 4'-O-methyltransferase
2.1.1.231
flavonoid 4'-O-methyltransferase
2.1.1.46
isoflavone 4'-O-methyltransferase
|
–
–
–
|
| |
BRENDA:
BS289634
KEGG:
R06564
MetaCyc:
RXN-3542
|
|
|
|
(-)-Medicocarpin <=> medicarpin
|
not assigned
|
–
|
| |
KEGG:
R07743
|
|
|
|
Medicarpin_3-O-glucoside-6''-malonate <=> (-)-Medicocarpin
|
not assigned
|
–
|
| |
KEGG:
R07742
|
|
|
|
2''-Hydroxyformononetin <=> 7-Hydroxy-2'',4'',5''-trimethoxyisoflavone
|
not assigned
|
–
|
| |
KEGG:
R07735
|
|
|
|
(2R,3S)-2,7-dihydroxy-4''-methoxyisoflavanone <=> formononetin + H2O
|
4.2.1.105
2-hydroxyisoflavanone dehydratase
|
–
|
| |
BRENDA:
BS378892
KEGG:
R07723
MetaCyc:
RXN-3625
SABIO-RK:
10557
|
|
|
|
(6aS,11aS)-2-dimethylallyl-3,6a,9-trihydroxypterocarpan + reduced_flavodoxin + O2 <=> glyceollin_II + flavin + 2 H2O
|
1.14.14.135
glyceollin synthase
|
–
|
| |
BRENDA:
BR48493
KEGG:
R07195
|
|
|
|
(3R)2',7-dihydroxy-dihydro-4',5'-methylenedioxyisoflavone + NADP+ <=> 2''-hydroxypseudobaptigenin + NADPH + H+
|
1.3.1.45
2'-hydroxyisoflavone reductase
|
–
|
| |
BRENDA:
BS258567
KEGG:
R07751
MetaCyc:
RXN-3766
|
|
|
|
liquiritigenin + 2-oxoglutarate + O2 <=> 7,4''-dihydroxyflavone + succinate + CO2 + H2O
|
1.14.20.5
flavone synthase I
|
–
|
| |
BRENDA:
BS397707
KEGG:
R07712
|
|
|
|
(+)-maackiain <=> (+)-6a-hydroxymaackiain
|
not assigned
|
–
|
| |
KEGG:
R07749
|
|
|
|
daidzein <=> Anhydroglycinol
|
not assigned
|
–
|
| |
KEGG:
R07725
|
|
|
|
UDP-glucose + (-)-maackiain <=> H+ + (-)-maackiain_3-O-beta-D-glucoside + UDP
|
2.4.1.170
isoflavone 7-O-glucosyltransferase
|
–
|
| |
KEGG:
R07753
MetaCyc:
RXN-4319
|
|
|
|
(3R)2',7-dihydroxy-dihydro-4',5'-methylenedioxyisoflavone + NADPH + H+ <=> (-)-maackiain + NADP+ + H2O
|
not assigned
|
–
|
| |
KEGG:
R07752
|
|
|
|
2'',7-Dihydroxy-4'',5''-methylenedioxyisoflavone + NADPH + H+ <=> (+)-Sophorol + NADP+
|
1.3.1.45
2'-hydroxyisoflavone reductase
|
–
|
| |
KEGG:
R07747
|
|
|
|
Pratensein + reduced_flavodoxin + O2 <=> 5-hydroxypseudobaptigenin + flavin + 2 H2O
|
1.14.19.63
pseudobaptigenin synthase
|
–
|
| |
BRENDA:
BR49423
KEGG:
R09602
|
|
|
|
genistin + malonyl-CoA <=> genistein-7-O-glucosyl-6''-O-malonate + CoA
|
2.3.1.115
isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase
|
–
|
| |
BRENDA:
BS320325
KEGG:
R07757
MetaCyc:
RXN-3583
|
|
|
|
S-adenosyl-L-methionine + genistein <=> prunetin + S-adenosyl-L-homocysteine
|
2.1.1.150
isoflavone 7-O-methyltransferase
2.1.1.155
kaempferol 4'-O-methyltransferase
2.1.1.B75
|
–
–
–
|
| |
BRENDA:
BS415232
KEGG:
R06794
MetaCyc:
RXN-3642
SABIO-RK:
6369
|
|
|
|
biochanin_A_7-O-beta-D-glucopyranoside + malonyl-CoA <=> biochanin_A-7-O-glucoside-6''''-malonate + CoA
|
2.3.1.115
isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase
|
–
|
| |
BRENDA:
BR43978
KEGG:
R06796
MetaCyc:
RXN-4703
|
|
|
|
Biochanin_A + reduced_flavodoxin + O2 <=> Pratensein + flavin + H2O
|
1.14.14.88
isoflavone 3'-hydroxylase
|
–
|
| |
BRENDA:
BS186715
KEGG:
R07776
|
|
|
|
NADP+ + dihydrobiochanin-A <=> NADPH + Biochanin_A + H+
|
1.3.1.46
biochanin-A reductase
|
–
|
| |
BRENDA:
BR36828
KEGG:
R02954
MetaCyc:
BIOCHANIN-A-REDUCTASE-RXN
|
|
|
|
(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl_diphosphate <=> 2-(or_4-)dimethylallyl-(6aS,11aS)-3,6a,9-trihydroxypterocarpan + diphosphate
|
2.5.1.36
trihydroxypterocarpan dimethylallyltransferase
|
–
|
| |
BRENDA:
BR47362
KEGG:
R07272
MetaCyc:
RXN-4509
|
|
|
|
(-)-maackiain_3-O-beta-D-glucoside <=> (-)-maackiain
|
not assigned
|
–
|
| |
KEGG:
R07756
|
|
|
|
naringenin + reduced_flavodoxin + O2 <=> apigenin + flavin + 2 H2O
|
1.14.19.76
flavone synthase II
|
–
|
| |
BRENDA:
BS446316
KEGG:
R12278
|
|
|
|
2'-hydroxydihydrodaidzein <=> daidzein + H2O
|
4.2.1.105
2-hydroxyisoflavanone dehydratase
|
–
|
| |
BRENDA:
BR48537
KEGG:
R07317
MetaCyc:
RXN-3284
SABIO-RK:
8492
|
|
|
|
4'',6,7-Trihydroxyisoflavone <=> glycitein
|
not assigned
|
–
|
| |
KEGG:
R07717
|
|
|
|
medicarpin + NADPH + H+ <=> 7,2''-dihydroxy-4''-methoxyisoflavan + NADP+
|
1.1.1
1.23.1
1.3.1
|
–
–
–
|
| |
KEGG:
R07739
MetaCyc:
RXN-16255;
RXN-8936
|
|
|
|
liquiritigenin + reduced_flavodoxin + O2 <=> 7,4''-dihydroxyflavone + flavin + 2 H2O
|
1.14.19.76
flavone synthase II
|
–
|
| |
BRENDA:
BS446301
KEGG:
R12277
|
|
|
|
2,6,7,4''-tetrahydroxyisoflavanone <=> 6,7,4''-trihydroxyisoflavone + H2O
|
4.2.1
|
–
|
| |
KEGG:
R07716
MetaCyc:
RXN-7656
|
|
|
|
UDP-glucose + medicarpin <=> H+ + (-)-Medicocarpin + UDP
|
2.4.1.170
isoflavone 7-O-glucosyltransferase
|
–
|
| |
KEGG:
R07740
MetaCyc:
RXN-4201
|
|
|
|
Anhydroglycinol <=> coumestrol
|
not assigned
|
–
|
| |
KEGG:
R07726
MetaCyc:
RXN-11643
|
|
|
|
formononetin_7-O-glucoside + malonyl-CoA <=> formononetin-7-O-glucoside-6''''-malonate + CoA
|
2.3.1.115
isoflavone-7-O-beta-glucoside 6''-O-malonyltransferase
|
–
|
| |
BRENDA:
BS320324
KEGG:
R07731
MetaCyc:
RXN-4762
|
|
|
|
UDP-glucose + daidzein <=> H+ + daidzin + UDP
|
2.4.1.170
isoflavone 7-O-glucosyltransferase
|
–
|
| |
BRENDA:
BS322258
KEGG:
R07720
MetaCyc:
RXN-3584
|
|
